论文标题
补充传播协助衰减校正的定量心脏宠物/MR
Supplemental Transmission Aided Attenuation Correction for Quantitative Cardiac PET/MR
论文作者
论文摘要
心脏宠物/MR联合的定量宠物衰减校正(AC)是一个具有挑战性的问题。我们提出和评估一种AC方法,该方法使用相对较弱且物理上稀疏的外部来源的巧合,并结合患者的巧合,仅基于物理原理来纠正宠物衰减。源的30毫升量低使填充和放置易于填充,并且该方法不使用先前的图像数据或衰减图假设。我们的补充传播帮助最大似然性的衰减和活动(STX-MLAA)算法包含一个衰减图更新,该更新最大化了代表术语的可能性,代表来自患者词的偶然巧合的可能性,并且单独从外部来源分割了计数的加权表达。外部来源和患者分散以及随机的均得到完全纠正。我们与FDG PET/CT Phantom研究相比,我们评估了STX-MLAA的性能。包括对心肌炎症的患者进行建模。通过ROI分析,我们测量了与CT-AC相对于CT-AC产生的PET图像的活性浓度的偏差小于5%。与单独使用从传输源分割的AC相吻合相比,STX-MLAA的PET背景变异性(来自噪声和稀疏采样)大大降低了STX-MLAA。该研究表明,STX-MLAA将在PET/MR上产生PET图像,其定量与人类心脏检查期间的PET/CT结果相当。
Quantitative PET attenuation correction (AC) for combined cardiac PET/MR is a challenging problem. We propose and evaluate an AC approach that uses coincidences from a relatively weak and physically fixed sparse external source, in combination with that from the patient, to correct for PET attenuation based on physics principles alone. The low 30 ml volume of the source makes it easy to fill and place, and the method does not use prior image data or attenuation map assumptions. Our supplemental transmission aided maximum likelihood reconstruction of attenuation and activity (sTX-MLAA) algorithm contains an attenuation map update that maximizes the likelihood of terms representing coincidences originating from tracer in the patient and a weighted expression of counts segmented from the external source alone. Both external source and patient scatter and randoms are fully corrected. We evaluated performance of sTX-MLAA compared to reference standard CT-based AC with FDG PET/CT phantom studies; including modeling a patient with myocardial inflammation. Through an ROI analysis we measured less than 5% bias in activity concentrations for PET images generated with sTX-MLAA relative to CT-AC. PET background variability (from noise and sparse sampling) was substantially reduced with sTX-MLAA compared to using coincidences segmented from the transmission source alone for AC. The study suggests that sTX-MLAA will produce PET images on PET/MR with quantification comparable to PET/CT results during human cardiac exams.