学术文献库

First-episode schizophrenia (FES) results in abnormality of brain connectivity at different levels. Despite some successful findings on functional and structural connectivity of FES, relatively few studies have been focused on morphological connectivity, which may provide a potential biomarker for FES. In this study, we aim to investigate cortical morphological connectivity in FES. T1-weighted magnetic resonance image data from 92 FES patients and 106 healthy controls (HCs) are analyzed.We parcellate brain into 68 cortical regions, calculate the averaged thickness and surface area of each region, construct undirected networks by correlating cortical thickness or surface area measures across 68 regions for each group, and finally compute a variety of network-related topology characteristics. Our experimental results show that both the cortical thickness network and the surface area network in two groups are small-world networks; that is, those networks have high clustering coefficients and low characteristic path lengths. At certain network sparsity levels, both the cortical thickness network and the surface area network of FES have significantly lower clustering coefficients and local efficiencies than those of HC, indicating FES-related abnormalities in local connectivity and small-worldness. These abnormalities mainly involve the frontal, parietal, and temporal lobes. Further regional analyses confirm significant group differences in the node betweenness of the posterior cingulate gyrus for both the cortical thickness network and the surface area network. Our work supports that cortical morphological connectivity, which is constructed based on correlations across subjects' cortical thickness, may serve as a tool to study topological abnormalities in neurological disorders.