论文标题
拉伸与压缩弹性和渗透性的不对称性有助于调节胶原蛋白凝胶中的交换
Asymmetry of tensile vs. compressive elasticity and permeability contributes to the regulation of exchanges in collagen gels
论文作者
论文摘要
Starling原理根据静水和渗透流的平衡来描述组织中的交换。这种平衡忽略了力学和流体动力学之间的耦合，这是由于血管内压力引起的紧张弹性组织的可疑假设。在这里，我们通过比较在胶原板板的出口和分析动力学模型的空气腔中比较胶原蛋白凝胶和压缩应力下的胶原蛋白凝胶的弹性和渗透性。我们观察到在压缩下渗透性的下降和增强的天然胶原蛋白凝胶的应变膨胀，这两种作用在化学交联后基本上损失了。此外，我们证明这种不对称反应解释了正弦液注射时压缩应力的积累，这调节了材料的渗透性。因此，我们的结果表明，胶原蛋白的特性调节分子交换，并有助于了解组织中的药物运输。
The Starling principle describes exchanges in tissues based on the balance of hydrostatic and osmotic flows. This balance neglects the coupling between mechanics and hydrodynamics, a questionable assumption in strained elastic tissues due to intravascular pressure. Here, we measure the elasticity and permeability of collagen gels under tensile and compressive stress via the comparison of the temporal evolution of pressure in an air cavity sealed at the outlet of a collagen slab with an analytical kinetic model. We observe a drop in the permeability and enhanced strain-stiffening of native collagen gels under compression, both effects being essentially lost after chemical cross-linking. Further, we prove that this asymmetric response accounts for the accumulation of compressive stress upon sinusoidal fluid injection, which modulates the material's permeability. Our results thus show that the properties of collagen gels regulate molecular exchanges and could help understand drug transport in tissues.
