论文标题
使用MCNP6的实用放射治疗应用的质子硼融合反应评估
Assessment of the proton boron fusion reaction for practical radiation therapy applications using MCNP6
论文作者
论文摘要
使用MCNP6研究了质子硼融合反应11b（P，3α），以评估在放射治疗中潜在使用的生存力。 11B（P，3α）在理论上是可取的，因为它可以将局部剂量递送质子（Bragg Peak）与产生三个高的LETα颗粒局部沉积在肿瘤区域中。还使用MCNP6对质子铅笔梁和带有轴向区域的水幻影的质子梁进行了模拟，以确定硼对计算出的能量沉积的影响程度。进行的MCNP模拟表明，临床相关的硼浓度下的质子硼融合反应速率太小，无法对吸收剂量产生任何可测量的影响。据确定，在MCNPX/6中使用的11B（P，3α）反应没有良好的评估，并且应在横截面评估中进行进一步的工作，以便确定评估质子硼融合反应的可行性以用于放射治疗应用。
The proton boron fusion reaction, 11B(p, 3α), is investigated using MCNP6 to assess the viability for potential use in radiation therapy. The 11B(p, 3α) is theoretically desirable because it could combine the localized dose delivery protons exhibit (Bragg peak) with the creation of three high LET α particles that locally deposit energy in tumor regions. Simple simulations of a proton pencil beam incident upon a water phantom and a water phantom with an axial region also containing boron were modeled using MCNP6 in order to determine the extent of the impact boron had upon the calculated energy deposition. The MCNP simulations performed demonstrated that the proton boron fusion reaction rate at clinically relevant boron concentrations was too small in order to have any measurable impact on the absorbed dose. It was determined that there are no good evaluations of the 11B(p, 3α) reaction for use in MCNPX/6 and further work should be conducted in cross section evaluations in order to definitively evaluate the feasibility of the proton boron fusion reaction for use in radiation therapy applications.
