论文标题

紧凑的正交视图OCT:在细胞分辨率下对人小梁网和角膜的临床探索

Compact orthogonal view OCT: clinical exploration of human trabecular meshwork and cornea at cell resolution

论文作者

Mazlin, Viacheslav, Irsch, Kristina, Borderie, Vincent, Baudouin, Christophe, Paques, Michel, Fink, Mathias, Grieve, Kate, Boccara, Albert Claude

论文摘要

尽管今天有许多治疗选择,但青光眼仍然是失明的主要原因之一。有效的治疗需要早期诊断,这很难通过检测已经造成的不可逆后眼损伤的现有成像技术实现。一种改进的方法可能是检测前眼睛的小梁网隔板的变化,该距离之前的眼睛压力积聚和视力丧失。在这里,我们报告了一种设备,该设备可以在细胞分辨率下进行体内探索小梁网。该仪器结合了两个正交的视图:镜头全场OCT的脸部视图,用于光谱域OCT的高分辨率和横截面视图,以对齐网格工作。该设备可以分辨微米水平的角膜镜和紫veal孔,网状束和内部弹性纤维,纤毛身体肌腱和小梁细胞核。能够检测到小梁孔的阻塞,正交视图OCT为长期青光眼诊断的长期问题提供了有希望的解决方案。该设备的未来临床采用促进了紧凑的足迹和广泛的功能,包括使用相同的设计中的健康受试者和患者(与角膜纤维,佛法)内皮营养不良的患者(伴有角膜肌)进行角膜成像。

Glaucoma remains among the leading causes of blindness despite many treatment options available today. Effective treatment requires early diagnosis, which is difficult to achieve with existing imaging technologies that detect the already inflicted irreversible posterior eye damage. One improved approach could be to detect the changes in trabecular meshwork of the anterior eye that precede the intraocular pressure buildup and vision loss. Here we report a device that enables in vivo exploration of trabecular meshwork at cell resolution. The instrument combines two orthogonal views: en face view of time-domain full-field OCT for high-resolution and cross-sectional view of spectral-domain OCT for aligning to the meshwork. The device resolves micron-level corneoscleral and uveal pores, meshwork beams and internal elastic fibers, ciliary body tendons and trabecular cell nuclei. Capable of detecting blockage of trabecular pores, orthogonal view OCT presents a promising solution to the long-standing problem of early glaucoma diagnosis. Future clinical adoption of the device is facilitated by the compact footprint and broad functionality that includes corneal imaging in healthy subjects and patients (with keratoconus, Fuchs endothelial dystrophy) using the same design.

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