论文标题
通过全球和本地依赖性估算大脑年龄
Estimating Brain Age with Global and Local Dependencies
论文作者
论文摘要
事实证明,大脑时代是与认知表现和脑部疾病相关的表型。实现准确的脑年龄预测是优化预测的脑时代差异作为生物标志物的必要先决条件。作为一种综合的生物学特征,很难使用特征工程和局部处理的模型来准确利用大脑时代,例如局部卷积和一次经常处理一个本地社区的操作。取而代之的是,视觉变形金刚学习了斑块令牌的全球专心相互作用,引入了较少的电感偏差和建模远程依赖性。就此而言,我们提出了一个新型的网络,用于学习大脑年龄与全球和局部依赖性解释,其中相应的表示由连续排列的变压器(SPT)和卷积块捕获。 SPT带来了计算效率,并通过从不同视图中连续编码2D切片间接地定位了3D空间信息。最后,我们收集了一大批22645名受试者的队列,年龄从14到97不等,我们的网络在一系列深度学习方法中表现最好,在验证集中产生的平均绝对误差(MAE)为2.855,而在独立的测试集中产生了2.911。
The brain age has been proven to be a phenotype of relevance to cognitive performance and brain disease. Achieving accurate brain age prediction is an essential prerequisite for optimizing the predicted brain-age difference as a biomarker. As a comprehensive biological characteristic, the brain age is hard to be exploited accurately with models using feature engineering and local processing such as local convolution and recurrent operations that process one local neighborhood at a time. Instead, Vision Transformers learn global attentive interaction of patch tokens, introducing less inductive bias and modeling long-range dependencies. In terms of this, we proposed a novel network for learning brain age interpreting with global and local dependencies, where the corresponding representations are captured by Successive Permuted Transformer (SPT) and convolution blocks. The SPT brings computation efficiency and locates the 3D spatial information indirectly via continuously encoding 2D slices from different views. Finally, we collect a large cohort of 22645 subjects with ages ranging from 14 to 97 and our network performed the best among a series of deep learning methods, yielding a mean absolute error (MAE) of 2.855 in validation set, and 2.911 in an independent test set.