论文标题
具有异质尖峰阈值的神经网络的宏观动力学
Macroscopic Dynamics of Neural Networks with Heterogeneous Spiking Thresholds
论文作者
论文摘要
平均场理论将单个神经元的生理特性与神经种群活动的新兴动态联系起来。这些模型为研究不同尺度研究大脑功能提供了必不可少的工具。但是,为了大规模地应用神经种群,他们需要考虑不同神经元类型之间的差异。 Izhikevich单神经元模型可以解释各种不同的神经元类型和尖峰模式,从而使其成为异质网络中脑动力学的均值均值治疗方法的最佳候选者。在这里,我们得出了具有异质尖峰阈值的全部耦合Izhikevich神经元网络的平均场方程。使用分叉理论中的方法,我们研究了平均场理论准确预测Izhikevich神经元网络的动力学的条件。为此,我们关注Izhikevich模型的三个重要特征,这些特征在此处进行简化的假设:(i)尖峰频率适应,(ii)尖峰复位条件以及(iii)单细胞尖峰阈值在神经元中的分布。 我们的结果表明,虽然平均场模型不是Izhikevich网络动力学的确切模型,但它忠实地捕获了其不同的动态制度和相变。因此,我们提出了一个平均场模型,该模型可以代表不同的神经元类型和尖峰动力学。该模型由生物物理状态变量和参数组成,结合了逼真的尖峰重置条件,并说明了神经尖峰阈值的异质性。这些功能允许模型的广泛适用性以及与实验数据的直接比较。
Mean-field theory links the physiological properties of individual neurons to the emergent dynamics of neural population activity. These models provide an essential tool for studying brain function at different scales; however, for their application to neural populations on large scale, they need to account for differences between distinct neuron types. The Izhikevich single neuron model can account for a broad range of different neuron types and spiking patterns, thus rendering it an optimal candidate for a mean-field theoretic treatment of brain dynamics in heterogeneous networks. Here, we derive the mean-field equations for networks of all-to-all coupled Izhikevich neurons with heterogeneous spiking thresholds. Using methods from bifurcation theory, we examine the conditions under which the mean-field theory accurately predicts the dynamics of the Izhikevich neuron network. To this end, we focus on three important features of the Izhikevich model that are subject here to simplifying assumptions: (i) spike-frequency adaptation, (ii) the spike reset conditions, and (iii) the distribution of single-cell spike thresholds across neurons. Our results indicate that, while the mean-field model is not an exact model of the Izhikevich network dynamics, it faithfully captures its different dynamic regimes and phase transitions. We thus present a mean-field model that can represent different neuron types and spiking dynamics. The model is comprised of biophysical state variables and parameters, incorporates realistic spike resetting conditions, and accounts for heterogeneity in neural spiking thresholds. These features allow for a broad applicability of the model as well as for a direct comparison to experimental data.