论文标题
染料掺杂聚苯乙烯微球的瞬时结构变化的亚纳米测量
Sub-nanometer measurement of transient structural changes in dye-doped polystyrene microspheres
论文作者
论文摘要
我们提出了一种干涉光谱域光学相干断层扫描显微镜设置，以使用从样品的不同界面反射的光的干扰来检测结构变化。我们诱导染料掺杂的10 $ 〜μ $ m的纳米尺寸变化，通过通过调制的532 nm激光器激发的微球内染料分子的Stokes Shipt shipt shipt siply微球。以0.4 $ 〜pm/\ sqrt {hz} $限制了通过光调检噪声限制的灵敏度测量所得的光路长度差，并揭示了弹性和非弹性响应，这为测量细胞大小的生物学对象的响应打开了可能性。
We present an interferometric spectral-domain optical coherence tomography microscopy setup to detect structural changes using interference of light reflected from different interfaces of the sample. We induce a reproducible nanometer-scale size change in dye-doped 10$~μ$m polystyrene microspheres by the release of Stokes shift energy of dye molecules inside the microspheres, excited by a modulated 532-nm laser. The resulting optical path length difference was measured with a sensitivity of 0.4$~pm/\sqrt{Hz}$ limited by photodetection noise, and reveals elastic as well as inelastic responses, which opens up possibilities for measuring the response of cell-sized biological objects.
