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The lack of out-of-domain generalization is a critical weakness of deep networks for semantic segmentation. Previous studies relied on the assumption of a static model, i. e., once the training process is complete, model parameters remain fixed at test time. In this work, we challenge this premise with a self-adaptive approach for semantic segmentation that adjusts the inference process to each input sample. Self-adaptation operates on two levels. First, it fine-tunes the parameters of convolutional layers to the input image using consistency regularization. Second, in Batch Normalization layers, self-adaptation interpolates between the training and the reference distribution derived from a single test sample. Despite both techniques being well known in the literature, their combination sets new state-of-the-art accuracy on synthetic-to-real generalization benchmarks. Our empirical study suggests that self-adaptation may complement the established practice of model regularization at training time for improving deep network generalization to out-of-domain data. Our code and pre-trained models are available at https://github.com/visinf/self-adaptive.