论文标题
具有极化敏感的光声音矩阵矩阵层摄影术中阿尔茨海默氏病中淀粉样斑块的无标记可视化
Label free visualization of amyloid plaques in Alzheimer's disease with polarization-sensitive photoacoustic Mueller matrix tomography
论文作者
论文摘要
由细胞外淀粉样蛋白的异常沉积引起的皮质和海马大脑区域中淀粉样木质的形成高度挑战的任务。在此，通过巧妙地提取通过光声（PA）技术对淀粉样蛋白斑块的极化敏感的光吸收，这是一种新型的PA Mueller矩阵（PAMM）层造影，该技术能够提供三个新的分子构象参数，以实现深度分辨出的深度标记标记的amyyloid plaees。已经在APP/PS1转基因AD小鼠的不同阶段进行的全脑PAMM成像，以证明其原位/体内定量三维（3D）检测淀粉样蛋白斑块的能力，并且其在不标记不标记的情况下监测早期AD病理学发育的巨大潜力。
The formation of amyloid plaques in the cortical and hippocampal brain regions caused by abnormal deposition of extracellular amyloid \b{eta}-protein (A\b{eta}) is a characteristic pathological hallmark of early Alzheimer's disease (AD), while label-free graphic rendering of diseased amyloid plaques in vivo is still a highly challenging task. Herein, by ingeniously extracting the polarization-sensitive optical absorption of amyloid plaques via photoacoustic (PA) technique, a novel PA Mueller matrix (PAMM) tomography that capable of providing three new conformational parameters of molecules is developed to realize depth-resolved label-free imaging of amyloid plaques. Whole brain PAMM imaging on different stages of APP/PS1 transgenic AD mice has been performed to demonstrate its ability for in situ/in vivo quantitative three-dimensional (3D) detection of amyloid plaques and its great potential for monitoring early AD pathological development without labeling.
