论文标题
从制造商的角度来看生命的起源 - 专注于自下而上的合成生物学中的原细胞隔室
Origin of life from a maker's perspective -- focus on protocellular compartments in bottom-up synthetic biology
论文作者
论文摘要
生命的起源被神秘笼罩着，几乎没有生存的线索，并被进化竞争所掩盖。先前的评论已经涉及自上而下和自下而上的合成生物学的互补方法，以增强我们对生活系统的理解。在这里，我们指出这些领域之间的协同作用，尤其是自下而上的合成生物学和生活的起源研究之间。我们探讨了与拥挤的细胞，其新陈代谢以及生长和分裂周期以及如何开始合并这些努力的人造细胞隔室取得的最新进展。尽管当前生活的复杂性是其最引人注目的特征之一，但人生的基本特征都不需要它，而且它们从一开始就不太可能出现因此复杂。当前的研究没有恢复一个真正的起源，而是通过挑逗一组基本组成部分而产生的复杂性和进化来促进最小生命的出现。
The origin of life is shrouded in mystery, with few surviving clues, obscured by evolutionary competition. Previous reviews have touched on the complementary approaches of top-down and bottom-up synthetic biology to augment our understanding of living systems. Here we point out the synergies between these fields, especially between bottom-up synthetic biology and origin of life research. We explore recent progress made in artificial cell compartmentation in line with the crowded cell, its metabolism, as well as cycles of growth and division, and how those efforts are starting to be combined. Though the complexity of current life is among its most striking characteristics, none of life's essential features require it, and they are unlikely to have emerged thus complex from the beginning. Rather than recovering the one true origin lost in time, current research converges towards reproducing the emergence of minimal life, by teasing out how complexity and evolution may arise from a set of essential components.
