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Human affect and mental state estimation in an automated manner, face a number of difficulties, including learning from labels with poor or no temporal resolution, learning from few datasets with little data (often due to confidentiality constraints) and, (very) long, in-the-wild videos. For these reasons, deep learning methodologies tend to overfit, that is, arrive at latent representations with poor generalisation performance on the final regression task. To overcome this, in this work, we introduce two complementary contributions. First, we introduce a novel relational loss for multilabel regression and ordinal problems that regularises learning and leads to better generalisation. The proposed loss uses label vector inter-relational information to learn better latent representations by aligning batch label distances to the distances in the latent feature space. Second, we utilise a two-stage attention architecture that estimates a target for each clip by using features from the neighbouring clips as temporal context. We evaluate the proposed methodology on both continuous affect and schizophrenia severity estimation problems, as there are methodological and contextual parallels between the two. Experimental results demonstrate that the proposed methodology outperforms all baselines. In the domain of schizophrenia, the proposed methodology outperforms previous state-of-the-art by a large margin, achieving a PCC of up to 78% performance close to that of human experts (85%) and much higher than previous works (uplift of up to 40%). In the case of affect recognition, we outperform previous vision-based methods in terms of CCC on both the OMG and the AMIGOS datasets. Specifically for AMIGOS, we outperform previous SoTA CCC for both arousal and valence by 9% and 13% respectively, and in the OMG dataset we outperform previous vision works by up to 5% for both arousal and valence.