论文标题
16通道的低功率神经连通性提取和相锁的深脑刺激SOC
A 16-Channel Low-Power Neural Connectivity Extraction and Phase-Locked Deep Brain Stimulation SoC
论文作者
论文摘要
越来越多的证据表明，相锁的深脑刺激（DBS）可以有效地调节神经和精神疾病中的脑连通性异常。因此，这封信提供了具有神经连通性提取和锁相DBS功能的低功率SOC。一个16通道的低噪声模拟前端（AFE）记录了来自多个大脑区域的局部场势（LFP），具有精确的增益匹配。一种新型的低复杂相估计器和神经连通性处理器随后实现了瞬时相和跨区域同步测量的能量效率但准确的测量。通过神经生物标志物（如相位同步和光谱能）的柔性组合，触发了四通道电荷平衡的神经刺激剂来治疗各种病理大脑条件。该Soc在65nm CMOs制造的硅面积为2.24mm2，消耗了60UW，与最先进的ART相比，神经连通性提取的节省60％以上。广泛的体内测量表明，大鼠的多通道LFP记录，相和神经连通性测量的实时提取以及相锁的刺激。
Growing evidence suggests that phase-locked deep brain stimulation (DBS) can effectively regulate abnormal brain connectivity in neurological and psychiatric disorders. This letter therefore presents a low-power SoC with both neural connectivity extraction and phase-locked DBS capabilities. A 16-channel low-noise analog front-end (AFE) records local field potentials (LFPs) from multiple brain regions with precise gain matching. A novel low-complexity phase estimator and neural connectivity processor subsequently enable energy-efficient, yet accurate measurement of the instantaneous phase and cross-regional synchrony measures. Through flexible combination of neural biomarkers such as phase synchrony and spectral energy, a four-channel charge-balanced neurostimulator is triggered to treat various pathological brain conditions. Fabricated in 65nm CMOS, the SoC occupies a silicon area of 2.24mm2 and consumes 60uW, achieving over 60% power saving in neural connectivity extraction compared to the state-of-the-art. Extensive in-vivo measurements demonstrate multi-channel LFP recording, real-time extraction of phase and neural connectivity measures, and phase-locked stimulation in rats.
