论文标题
受体均匀性在多价结合中的作用
The role of receptor uniformity in multivalent binding
论文作者
论文摘要
由于多价结合的合作性产生的超选择性，多种生物系统和应用中的多相关性很普遍。传统上，人们认为，较弱的个人结合将提高多价靶向的选择性。在这里，使用分析平均场理论和蒙特卡洛模拟，我们发现，对于高度均匀分布的受体，最高的选择性发生在中间结合能，并且可以显着大于弱结合极限。这是由结合分数和受体浓度之间的指数关系引起的，这受结合的强度和组合熵的影响。我们的发现不仅为使用多价纳米粒子的生物传感器的合理设计提供了新的指南，而且还引入了一种新的观点，以理解涉及多价性的生物学过程。
Multivalency is prevalent in various biological systems and applications due to the superselectivity that arises from the cooperativity of multivalent binding. Traditionally, it was thought that weaker individual binding would improve the selectivity in multivalent targeting. Here using analytical mean field theory and Monte Carlo simulations, we discover that for receptors that are highly uniformly distributed, the highest selectivity occurs at an intermediate binding energy and can be significantly greater than the weak binding limit. This is caused by an exponential relationship between the bound fraction and receptor concentration, which is influenced by both the strength and combinatorial entropy of binding. Our findings not only provide new guidelines for the rational design of biosensors using multivalent nano-particles but also introduce a new perspective in understanding biological processes involving multivalency.
