论文标题
细菌生长和分裂对生物膜结构特性的影响。计算机模拟研究
Influence of homeostatic mechanisms of bacterial growth and division on structural properties of biofilms. A computer simulation study
论文作者
论文摘要
细菌生长和分裂通常通过称为二元裂变的过程发生，在该过程中，细胞会极化直到分成两个子细胞。尽管该过程受到生长速率和子细胞长度引入随机变化的因素的影响，但事实是，细菌群落（也称为生物膜）的尺寸分布会随时间稳定。这表明存在稳态机制，这些机制有助于保持稳定的尺寸分布。那些被称为Sizer和Adder的人在这些机制中脱颖而出，这些机制并未完全确定。在这项工作中，使用基于代理模型的计算机仿真来研究这些稳态机制对发育生物膜的几何和结构特性的影响，重点是其开发的早期阶段。同样，还检查了线性或指数依赖性与细胞生长时间对这些特性的影响。从我们的研究中，我们推断出这些机制对所研究的特性没有明显的影响，这可能是由于随机因素在细胞分裂和生长过程中发挥作用的重要性。此外，我们讨论细胞生长与扩散之间的竞争是解释发展细菌菌落的结构和几何形状的关键方面。
Bacterial growth and division generally occur by the process known as binary fission, in which the cells grow polarly until they divide into two daughter cells. Although this process is affected by factors that introduce stochastic variability in both growth rate and daughter cell length, the fact is that the size distribution in bacterial communities, also known as biofilm, remains stable over time. This suggests the existence of homeostatic mechanisms that contribute to maintaining a stable size distribution. Those known as sizer and adder stand out among these mechanisms whose relevance is not entirely determined. In this work, computer simulations using an agent-based model, are used to study the effect of these homeostatic mechanisms on the geometrical and structural properties of the developing biofilm, focusing on the early stages of its development. Also, it was examined the effect of linear or exponential dependence with the time of cellular growth on these properties. From our study, we deduce that these mechanisms do not have a noticeable impact on the properties studied, which could be due to the importance that stochastic factors play in the cell division and growth process. In addition, we discuss how competition between cell growth and diffusion is a key aspect in explaining the structure and geometry of developing bacterial colonies.
