论文标题
涉及疏水聚电解质的合作过渡
Cooperative transitions involving hydrophobic polyelectrolytes
论文作者
论文摘要
疏水聚电解质（HPE）可以溶解双层膜，形成胶束或可以作为pH的函数可逆地聚集。过渡通常非常敏锐。我们表明，这些合作转变是通过两个或多个构象状态之间的竞争发生的，可以在Monod -Wymann -Changeux（MWC）理论的框架内解释，该理论最初是为变构相互作用而制定的。在这里，我们关注HPE对双层膜的pH依赖性不稳定和渗透。我们制定了一般条件，导致尖锐的构象转变，涉及由分子配体浓度变化介导的简单大分子。这打开了从药物到开发可切换材料的潜在应用。
Hydrophobic polyelectrolytes (HPE) can solubilize bilayer membranes, form micelles or can reversibly aggregate as a function of pH. The transitions are often remarkably sharp. We show that these cooperative transitions occur by a competition between two or more conformational states and can be explained within the framework of Monod - Wymann - Changeux (MWC) theory that was originally formulated for allosteric interactions. Here we focus on the pH-dependent destabilization and permeation of bilayer membranes by HPE. We formulate the general conditions that lead to sharp conformational transitions involving simple macromolecules mediated by concentration variations of molecular ligands. That opens up potential applications ranging from medicine to the development of switchable materials.
