论文标题
在干扰模型下的圆形设计
Circular designs for total effects under interference models
论文作者
论文摘要
本文研究了干涉模型的圆形设计,其中分配给图块的处理也影响了一个块内的相邻图。为了估算总效果,循环邻居平衡的设计在设计中被证明是普遍的最佳选择,这些设计不允许治疗成为自己的邻居。我们的研究表明,自我延伸的块序列实际上是最佳设计的主要成分。在这里,我们在整个设计空间中采用了近似设计框架和研究最佳设计。我们的方法足够灵活,可以容纳所有可能的设计参数,即块大小以及块和处理的数量。该方法可以分为两个主要步骤:识别最小座序序列及其构建的最佳条件的识别。前者对于将计算时间从几乎无穷大降至秒都至关重要。同时,通常通过数值方法可以实现查找最小设置的任务,该方法只能处理小块大小。我们的方法是一种混合性质,以应对所有设计尺寸。当块大小不大时,我们会提供最小设置的明确表达式,而不是依赖数值方法。对于较大的块大小,当典型的数值方法失败时,我们从理论上得出了合理的大小中间序列集,从中可以通过自定义算法快速得出最小的集合。进一步,最佳条件使我们能够获得对称和不对称设计。最后,我们还研究了循环设计和非圆形设计之间的权衡问题,并提供了有关选择的指南。
This paper studies circular designs for interference models, where a treatment assigned to a plot also affects its neighboring plots within a block. For the purpose of estimating total effects, the circular neighbor balanced design was shown to be universally optimal among designs which do not allow treatments to be neighbors of themselves. Our study shows that self-neighboring block sequences are actually the main ingredient for an optimal design. Here, we adopt the approximate design framework and study optimal designs in the whole design space. Our approach is flexible enough to accommodate all possible design parameters, that is the block size and the number of blocks and treatments. This approach can be broken down into two main steps: the identification of the minimal supporting set of block sequences and the optimality condition built on it. The former is critical for reducing the computational time from almost infinity to seconds. Meanwhile, the task of finding the minimal set is normally achieved through numerical methods, which can only handle small block sizes. Our approach is of a hybrid nature in order to deal with all design sizes. When block size is not large, we provide explicit expressions of the minimal set instead of relying on numerical methods. For larger block sizes when a typical numerical method would fail, we theoretically derived a reasonable size intermediate set of sequences, from which the minimal set can be quickly derived through a customized algorithm. Taking it further, the optimality conditions allow us to obtain both symmetric and asymmetric designs. Lastly, we also investigate the trade-off issue between circular and noncircular designs, and provide guidelines on the choices.