论文标题
在兴奋性边缘平衡：对细胞运动的影响
Balancing at the edge of excitability: Implications for cell movement
论文作者
论文摘要
细胞依靠感知和应对趋化因子浓度的小空间差异的能力以生存。越来越多的证据表明，这是通过将信号系统设置在激活系统中激活阈值附近，并使用空间异质性改变阈值的阈值，从而在梯度方向上偏置细胞活性，从而实现这一目标。在这里，我们考虑了一个方案，通过该方案，设定点在分叉点附近自适应设置，但没有明确的了解。通过模拟，我们表明该方法将提高细胞的趋化效率。本文的结果是基于爱德华多·桑塔格（Eduardo Sontag）和同事的开创性工作，本文专门为纪念他的70岁生日而奉献给他们。
Cells rely on the ability to sense and respond to small spatial differences in chemoattractant concentrations for survival. There is growing evidence that this is accomplished by setting the signaling system near the threshold for activation in an excitable system and using the spatial heterogeneities to alter the threshold thereby biasing cell activity in the direction of the gradient. Here we consider a scheme by which the set point is adaptively set near the bifurcation point, but without explicit knowledge of this point. Through simulation, we show that the method would improve chemotactic efficiency of cells. The results of this paper are based on pioneering work by Eduardo Sontag and coworkers, to whom this paper is dedicated in honor of his 70th birthday.
