论文标题
近场探测光学超细胞以增强生物检测
Near-field Probing of Optical Superchirality for Enhanced Bio-detection
论文作者
论文摘要
从理论上讲，纳米光量平台可以通过其诱发的近场的手性不对称的高度局部变化来检测手性生物学和药物分子的效果。然而，当前的手性纳米光子策略在本质上受到限制，因为它们依赖于对受性分子影响的远场光学测量值对近场敏感的敏感。因此，它们取决于检测远场光学响应限制检测敏感性的小变化。在这里，我们利用了有趣的现象，等离激元圆周极化发光（PCPL），这是近场手性的尖锐局部探针。这允许手性检测从头设计的肽的单层数量，该肽无法通过远场反应而实现。我们的工作表明，通过利用PCPL的近场灵敏度利用纳米光子平台的能力，可以实现最佳的生物分子检测性能，从而为纳米量学开辟了新的途径。
Nanophotonic platforms in theory uniquely enable < femtomoles of chiral biological and pharmaceutical molecules to be detected, through the highly localised changes in the chiral asymmetries of the near-fields that they induce. However, current chiral nanophotonic based strategies are intrinsically limited because they rely on far-field optical measurements that are sensitive to a much larger near-field volume, than that influenced by the chiral molecules. Consequently, they depend on detecting small changes in far-field optical response restricting detection sensitivities. Here we exploit an intriguing phenomenon, plasmonic circularly polarised luminescence (PCPL), which is an incisive local probe of near-field chirality. This allows chiral detection of monolayer quantities of a de novo designed peptide, which is not achieved with a far-field response. Our work demonstrates that by leveraging the capabilities of nanophotonic platforms with the near-field sensitivity of PCPL, optimal biomolecular detection performance can be achieved, opening new avenues for nanometrology.
