论文标题

OTFPF:基于3D重叠的脑年龄估计的最佳基于运输的特征金字塔融合网络

OTFPF: Optimal Transport-Based Feature Pyramid Fusion Network for Brain Age Estimation with 3D Overlapped ConvNeXt

论文作者

Fu, Yu, Huang, Yanyan, Wang, Yalin, Dong, Shunjie, Xue, Le, Yin, Xunzhao, Yang, Qianqian, Shi, Yiyu, Zhuo, Cheng

论文摘要

可以使用来自T1加权磁共振图像(T1 MRI)的深神经网络来预测健康大脑的年龄,并且预测的大脑年龄可以作为检测与衰老相关疾病或疾病的有效生物标志物。在本文中,我们提出了一个端到端的神经网络结构,称为基于最佳传输的特征金字塔融合(OTFPF)网络,以使用T1 MRI进行大脑年龄估计。 OTFPF由三种类型的模块组成:基于最佳传输的特征金字塔融合(OTFPF)模块,3D重叠的convnext(3D ol-convnext)模块和融合模块。这些模块增强了OTFPF网络对每个大脑的半峰值和多级特征金字塔信息的理解,并显着改善了其估计性能。与最新的最新模型相比,提出的OTFPF收敛速度更快,并且性能更好。 11,728年度3-97岁的MRI的实验表明,OTFPF网络可以提供准确的脑年龄估计,平均绝对误差(MAE)为2.097,Pearson的相关系数(PCC)为0.993,Spearman的等级相关系数(SRCC)为0.989和0.989之间,估计为0.989,估计为0.989,估计。广泛的定量实验和消融实验证明了OTFPF网络的优势和合理性。最终决定之后,代码和实施详细信息将在GitHub:https://github.com/zju-brain/otfpf上发布。

Chronological age of healthy brain is able to be predicted using deep neural networks from T1-weighted magnetic resonance images (T1 MRIs), and the predicted brain age could serve as an effective biomarker for detecting aging-related diseases or disorders. In this paper, we propose an end-to-end neural network architecture, referred to as optimal transport based feature pyramid fusion (OTFPF) network, for the brain age estimation with T1 MRIs. The OTFPF consists of three types of modules: Optimal Transport based Feature Pyramid Fusion (OTFPF) module, 3D overlapped ConvNeXt (3D OL-ConvNeXt) module and fusion module. These modules strengthen the OTFPF network's understanding of each brain's semi-multimodal and multi-level feature pyramid information, and significantly improve its estimation performances. Comparing with recent state-of-the-art models, the proposed OTFPF converges faster and performs better. The experiments with 11,728 MRIs aged 3-97 years show that OTFPF network could provide accurate brain age estimation, yielding mean absolute error (MAE) of 2.097, Pearson's correlation coefficient (PCC) of 0.993 and Spearman's rank correlation coefficient (SRCC) of 0.989, between the estimated and chronological ages. Widespread quantitative experiments and ablation experiments demonstrate the superiority and rationality of OTFPF network. The codes and implement details will be released on GitHub: https://github.com/ZJU-Brain/OTFPF after final decision.

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