论文标题

准真实时间多频3D剪切波绝对振荡 - 前列腺系统系统

Quasi-Real Time Multi-Frequency 3D Shear Wave Absolute Vibro-Elastography (S-WAVE) System for Prostate

论文作者

Aleef, Tajwar Abrar, Lobo, Julio, Baghani, Ali, Eskandari, Hani, Moradi, Hamid, Rohling, Robert, Goldenberg, S. Larry, Morris, William James, Mahdavi, S. Sara, Salcudean, Septimiu E.

论文摘要

本文介绍了一种新的准真实时间系统,用于对前列腺中组织弹性的定量和体积测量。通过使用局部频率估计器来测量前列腺内稳态剪切波的三维局部波长来计算组织弹性。剪切波是使用机械语音线圈振荡器创建的,该机械语音线圈振动振动振动振动振动振动振动振动振动振动振动振动振动振动振动振动振动振动振动振动振动振动板。射频数据直接从BK Medical 8848反直肠超声传感器流到外部计算机,在该计算机中,使用斑点跟踪算法测量了由于激发而引起的组织位移。使用带通采样,以消除对超快速帧速率跟踪组织运动的需求,并以低于Nyquist速率的采样频率进行准确的重建。带有计算机控制的滚动电动机用于旋转传感器的矢状阵列并获得3D数据。使用两个CIRS幻象来验证弹性测量的准确性以及使用系统进行体内前列腺成像的功能可行性。该系统已在两项独立的临床研究中用作癌症鉴定的方法。此处介绍的结果显示了我们的僵硬测量和癌症可能性之间的数值和视觉相关性,如病理学结果所确定。使用该系统的初始发布的结果包括在接收器操作特征曲线下为0.82 +/- 0.01的区域,涉及外围区域的前列腺癌鉴定。

This article describes a novel quasi-real time system for quantitative and volumetric measurement of tissue elasticity in the prostate. Tissue elasticity is computed by using a local frequency estimator to measure the three dimensional local wavelengths of a steady-state shear wave within the prostate gland. The shear wave is created using a mechanical voice coil shaker which transmits multi-frequency vibrations transperineally. Radio frequency data is streamed directly from a BK Medical 8848 trans-rectal ultrasound transducer to an external computer where tissue displacement due to the excitation is measured using a speckle tracking algorithm. Bandpass sampling is used that eliminates the need for an ultra fast frame rate to track the tissue motion and allows for accurate reconstruction at a sampling frequency that is below the Nyquist rate. A roll motor with computer control is used to rotate the sagittal array of the transducer and obtain the 3D data. Two CIRS phantoms were used to validate both the accuracy of the elasticity measurement as well as the functional feasibility of using the system for in vivo prostate imaging. The system has been used in two separate clinical studies as a method for cancer identification. The results, presented here, show numerical and visual correlations between our stiffness measurements and cancer likelihood as determined from pathology results. Initial published results using this system include an area under the receiver operating characteristic curve of 0.82+/-0.01 with regards to prostate cancer identification in the peripheral zone.

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