论文标题
1型糖尿病患者的闭环治疗的大规模虚拟临床试验
Large-scale Virtual Clinical Trials of Closed-loop Treatments for People with Type 1 Diabetes
论文作者
论文摘要
我们提出了一项虚拟临床试验，用于评估实际临床试验之前闭环糖尿病治疗的安全性和功效。这种虚拟试验可以对算法进行快速且无风险的审前测试，并且可以用于比较大型和多样化人群的不同治疗变化。参与者由多个数学模型表示，由随机微分方程组成，我们使用Monte Carlo闭环模拟来计算闭环处理的详细统计。我们使用高性能软件和硬件实施虚拟临床试验，并提出了一个示例试验，其中两个数学模型在52〜周内（即两百万个模拟），可以在2〜h 9〜分钟内完成。
We propose a virtual clinical trial for assessing the safety and efficacy of closed-loop diabetes treatments prior to an actual clinical trial. Such virtual trials enable rapid and risk-free pretrial testing of algorithms, and they can be used to compare different treatment variations for large and diverse populations. The participants are represented by multiple mathematical models, consisting of stochastic differential equations, and we use Monte Carlo closed-loop simulations to compute detailed statistics of the closed-loop treatments. We implement the virtual clinical trial using high-performance software and hardware, and we present an example trial with two mathematical models of one~million participants over 52~weeks (i.e., two~million simulations), which can be completed in 2~h 9~min.
