论文标题
P（VDF-TRFE）/BATIO3纳米颗粒复合膜介导压电刺激并促进SH-SY5Y神经母细胞细胞的分化
P(VDF-TrFE)/BaTiO3 nanoparticle composite films mediate piezoelectric stimulation and promote differentiation of SH-SY5Y neuroblastoma cells
论文作者
论文摘要
准备并测试通过直接通过直接的piezoepectric效应，准备并测试聚（乙烯基氟化物三氟乙烯，P（VDF-TRFE））和P（VDF-TRFE）/P（VDF-TRFE）/钛钛纳米颗粒（BTNP）膜（BTNP）膜（BTNP）膜。在SH-SY5Y细胞进行体外测试之前，膜的表面，机械和压电特征的特征是。特别是，BTNP显着改善了膜的压电特性（D31增加了4.5倍）。两种电影都支持良好的SH-SY5Y生存能力和分化。超声（US）刺激已被证明会引起Ca2+瞬变，并增强在压电底物上生长的细胞的分化。这项研究首次证明了聚合物/陶瓷复合膜和美国通过直接压电效应的神经元刺激的适用性。
Poly(vinylidene fluoride-trifluoroethylene, P(VDF-TrFE)) and P(VDF-TrFE)/barium titanate nanoparticle (BTNP) films are prepared and tested as substrates for neuronal stimulation through direct piezoelectric effect. Films are characterized in terms of surface, mechanical, and piezoelectric features before in vitro testing on SH-SY5Y cells. In particular, BTNPs significantly improve piezoelectric properties of the films (4.5-fold increased d31). Both kinds of films support good SH-SY5Y viability and differentiation. Ultrasound (US) stimulation is proven to elicit Ca2+ transients and to enhance differentiation in cells grown on the piezoelectric substrates. For the first time in the literature, this study demonstrates the suitability of polymer/ceramic composite films and US for neuronal stimulation through direct piezoelectric effect.
