论文标题

在多模态医学图像上,用于宫颈癌放射疗法的骨髓释放

Bone marrow sparing for cervical cancer radiotherapy on multimodality medical images

论文作者

Wang, Yuening, Sun, Ying, Yuan, Jie, Gan, Kexin, Xu, Hanzi, Gao, Han, Zhang, Xiuming

论文摘要

宫颈癌严重威胁了妇女的健康。放射疗法是主要治疗方法之一,但具有急性血液毒性的高风险。使用计算机断层扫描图像(CT)图像在放射疗法之前进行计划,以便在放射疗法之前有效地避免这种风险。与磁共振(MR)图像相比,CT缺乏表达BM活性的能力。因此,在当前的临床实践中,医生通过与MR图像相对应手动描述CT图像上的BM。但是,由于CT-MR多模式图像的不一致而,手工消耗删除BM的时间无法保证准确性。在这项研究中,我们提出了一种针对骨盆BM的多模式图像的自动登记方法,该方法由三维骨点云重建组成,这是一种局部球形系统迭代,最接近标记CT图像BM的最接近的点注册。在患者数据集上进行的实验表明,我们提出的方法可以提高医生在宫颈癌放射疗法的BM中的多模式图像登记精度和效率。此贡献中提出的方法还可能为其他临床应用中的类似研究提供参考。

Cervical cancer threatens the health of women seriously. Radiotherapy is one of the main therapy methods but with high risk of acute hematologic toxicity. Delineating the bone marrow (BM) for sparing using computer tomography (CT) images to plan before radiotherapy can effectively avoid this risk. Comparing with magnetic resonance (MR) images, CT lacks the ability to express the activity of BM. Thus, in current clinical practice, medical practitioners manually delineate the BM on CT images by corresponding to MR images. However, the time?consuming delineating BM by hand cannot guarantee the accuracy due to the inconsistency of the CT-MR multimodal images. In this study, we propose a multimodal image oriented automatic registration method for pelvic BM sparing, which consists of three-dimensional bone point cloud reconstruction, a local spherical system iteration closest point registration for marking BM on CT images. Experiments on patient dataset reveal that our proposed method can enhance the multimodal image registration accuracy and efficiency for medical practitioners in sparing BM of cervical cancer radiotherapy. The method proposed in this contribution might also provide references for similar studies in other clinical application.

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