论文标题
主动力学的强大分子计算
Robust Molecular Computation by Active Mechanics
论文作者
论文摘要
活细胞花费充满活力和物质资源,以可靠地从其环境中处理信息。为此,它利用了受热和其他波动的不可靠分子电路。在这里,我们认为主动的物理过程可以为信息处理提供错误纠正机制。我们分析了一个模型,在该模型中,波动受体激活会引起收缩应力,从而募集进一步的受体,动态控制资源使用和准确性。我们表明,这种主动方案可以胜过被动的静态簇(例如,通过蛋白质交联形成)。我们考虑简单的二进制环境,内容丰富的决策树和化学计算;在每种情况下,主动应力都用于构建动态抑制误差并允许强大的蜂窝计算的信号平台。
The living cell expends energetic and material resources to reliably process information from its environment. To do so, it utilises unreliable molecular circuitry that is subject to thermal and other fluctuations. Here, we argue that active, physical processes can provide error correcting mechanisms for information processing. We analyse a model in which fluctuating receptor activation induces contractile stresses that recruit further receptors, dynamically controlling resource usage and accuracy. We show that this active scheme can outperform passive, static clusters (as formed, for instance, by protein crosslinking). We consider simple binary environments, informative decision trees, and chemical computations; in each case, active stresses serve to contextually build signalling platforms that dynamically suppress error and allows for robust cellular computation.