论文标题
改善治疗时代基于生物标志物的HIV发病率估计
Improving Biomarker Based HIV Incidence Estimation in the Treatment Era
论文作者
论文摘要
在横截面调查中使用生物标志物测定估算HIV-1的发生率对于理解HIV大流行很重要。然而，这些估计的效用受到用于错误的恢复率（FRR）和最近感染的平均持续时间（MDRI）的不确定性的限制。本文展示了与治疗人群相比，人群的测试和诊断如何减少FRR和MDRI。使用自我报告的测试历史记录，提出了一种新方法来计算FRR和MDRI的适当上下文估计值。其结果是一种新的发病率，仅取决于参考FRR和MDRI参数，该参数得出了未诊断的，未诊断的，非精英控制器，非AIDS促进的人群。
Estimating HIV-1 incidence using biomarker assays in cross-sectional surveys is important for understanding the HIV pandemic. However, the utility of these estimates has been limited by uncertainty about what input parameters to use for False Recency Rate (FRR) and Mean Duration of Recent Infection (MDRI) after applying recent infection testing algorithm (RITA). This article shows how testing and diagnosis in a population reduce both FRR and MDRI compared to a treatment-naive population. Using self-reported testing history, a new method is proposed for calculating appropriate context-specific estimates of FRR and MDRI. The result of this is a new formula for incidence that depends only on reference FRR and MDRI parameters derived in an undiagnosed, treatment-naive, non-elite controller, non-AIDS-progressed population.
