论文标题
有条件的生成网络推荐
Conditional Generation Net for Medication Recommendation
论文作者
论文摘要
根据患者的诊断,药物建议目标是提供适当的药物,这是诊所的关键任务。目前,该建议是由医生手动进行的。但是,对于复杂的病例,例如同时患有多种疾病的患者,即使对于经验丰富的医生,也很难提出体贴的建议。这敦促出现自动药物建议的出现,这可以帮助治疗诊断的疾病而不会引起有害的药物相互作用。对于临床价值而言,药物建议吸引了不断增长的研究兴趣。存在主要的药物建议作为多标签分类的药物建议,以预测药物的组合。在本文中,我们提出了有条件的生成网(Cognet),该网络引入了一种新颖的复制或预测机制来生成一组药物。鉴于患者,提议的模型首先检索了他或她的历史诊断和药物建议,并将其与当前诊断的关系挖掘。然后,在预测每种药物时,提出的模型决定是从以前的建议中复制药物还是预测新药物。这个过程与人类医生的决策过程非常相似。我们在公共模拟数据集上验证了所提出的模型,实验结果表明,所提出的模型可以胜过最先进的方法。
Medication recommendation targets to provide a proper set of medicines according to patients' diagnoses, which is a critical task in clinics. Currently, the recommendation is manually conducted by doctors. However, for complicated cases, like patients with multiple diseases at the same time, it's difficult to propose a considerate recommendation even for experienced doctors. This urges the emergence of automatic medication recommendation which can help treat the diagnosed diseases without causing harmful drug-drug interactions.Due to the clinical value, medication recommendation has attracted growing research interests.Existing works mainly formulate medication recommendation as a multi-label classification task to predict the set of medicines. In this paper, we propose the Conditional Generation Net (COGNet) which introduces a novel copy-or-predict mechanism to generate the set of medicines. Given a patient, the proposed model first retrieves his or her historical diagnoses and medication recommendations and mines their relationship with current diagnoses. Then in predicting each medicine, the proposed model decides whether to copy a medicine from previous recommendations or to predict a new one. This process is quite similar to the decision process of human doctors. We validate the proposed model on the public MIMIC data set, and the experimental results show that the proposed model can outperform state-of-the-art approaches.