论文标题
异质性对癌症的影响：游戏理论的观点
Effects of heterogeneity on cancer: a game theory perspective
论文作者
论文摘要
在这项研究中，我们使用Hawk-Dove游戏探索了癌细胞之间的相互作用。我们通过考虑由2或3种细胞组成的人群来分析肿瘤的异质性。我们确定哪些策略在2型和3型人口游戏中的进化稳定以及相应的预期收益。我们的结果表明，在2型人口游戏中最好的细胞的回报高于3型人口游戏中最好的细胞。将这些数学发现转化为肿瘤学领域表明，分支类型的肿瘤比标点型肿瘤较少。透明细胞肾细胞癌的一些组织学和基因组数据与这些结果一致。
In this study, we explore interactions between cancer cells by using the hawk-dove game. We analyze the heterogeneity of tumors by considering games with populations composed of 2 or 3 types of cells. We determine what strategies are evolutionarily stable in the 2-type and 3-type population games and the corresponding expected payoffs. Our results show that the payoff of the best-off cell in the 2-type population game is higher than that of the best-off cell in the 3-type population game. Translating these mathematical findings to the field of oncology suggests that a branching-type tumor pursues a less aggressive course than a punctuated-type one. Some histological and genomic data of clear cell renal cell carcinomas are consistent with these results.
