论文标题
在随机治疗成本限制下的个性化治疗规则
Individualized treatment rules under stochastic treatment cost constraints
论文作者
论文摘要
对个性化治疗规则的估计和评估已经进行了广泛的研究，但是现实的治疗资源限制在现有方法中受到了有限的关注。我们研究了一个环境，即根据协变量，在治疗成本是随机的情况下，根据协变量进行干预，以优化治疗成本限制下的平均反事实结果。在一个特别有趣的特殊情况下，与接受治疗的比例相对的限制，对应于鼓励治疗的仪器变量。对于这种情况，我们首先开发一种方法来估计最佳的个性化治疗规则。我们进一步构建了相对于给定的参考规则的相应平均治疗效果的渐近有效插入式估计器。
Estimation and evaluation of individualized treatment rules have been studied extensively, but real-world treatment resource constraints have received limited attention in existing methods. We investigate a setting in which treatment is intervened upon based on covariates to optimize the mean counterfactual outcome under treatment cost constraints when the treatment cost is random. In a particularly interesting special case, an instrumental variable corresponding to encouragement to treatment is intervened upon with constraints on the proportion receiving treatment. For such settings, we first develop a method to estimate optimal individualized treatment rules. We further construct an asymptotically efficient plug-in estimator of the corresponding average treatment effect relative to a given reference rule.
