论文标题
Prebötzinger复合物中的微电路同步和重尾突触重量分布有助于产生呼吸节奏
Microcircuit synchronization and heavy tailed synaptic weight distribution in preBötzinger Complex contribute to generation of breathing rhythm
论文作者
论文摘要
Prebötzinger综合体是哺乳动物的灵感节奏发电机，将灵感时间描述为运动图案。整个稀疏连接的网络中的尖峰同步会产生灵感爆发，尽管在每个呼吸周期中发作后具有可变的潜伏期，但具有可变的潜伏期。使用PreBötc节律微电路模型，我们检查了爆发的概率和潜伏期的变化，模仿实验。在具有实验确定的神经元和突触参数的1000点神经元的各种生理上合理的图中，定向Erdős-rényi图最佳地捕获了实验观察到的动力学。从机械上讲，prebötc（de）同步和振荡动力学受尖峰神经元的传出连通性调节，这些连通性通过输入收敛而大会扩增适度的前验证活性。此外，为了复制实验，需要对突触权重的对数正态分布，以增强收敛重合输入的功效。这些机制实现了非常健壮但灵活的PreBötc吸引力动力学，我们假设，代表整个大脑中通用的时间处理和决策计算基序。
The preBötzinger Complex, the mammalian inspiratory rhythm generator, encodes inspiratory time as motor pattern. Spike synchronization throughout this sparsely connected network generates inspiratory bursts albeit with variable latencies after preinspiratory activity onset in each breathing cycle. Using preBötC rhythmogenic microcircuit minimal models, we examined the variability in probability and latency to burst, mimicking experiments. Among various physiologically plausible graphs of 1000 point neurons with experimentally determined neuronal and synaptic parameters, directed Erdős-Rényi graphs best captured the experimentally observed dynamics. Mechanistically, preBötC (de)synchronization and oscillatory dynamics are regulated by the efferent connectivity of spiking neurons that gates the amplification of modest preinspiratory activity through input convergence. Furthermore, to replicate experiments, a lognormal distribution of synaptic weights was necessary to augment the efficacy of convergent coincident inputs. These mechanisms enable exceptionally robust yet flexible preBötC attractor dynamics that, we postulate, represent universal temporal-processing and decision-making computational motifs throughout the brain.
