论文标题
肺分支形态发生的控制
The Control of Lung Branching Morphogenesis
论文作者
论文摘要
分支形态发生会产生上皮树，从而促进气体交换，过滤以及具有较大表面与体积比的分泌过程。在这篇综述中，我们关注控制肺分支形态发生早期阶段的发展机制。肺部分支形态发生涉及对新分支点的刻板印象，复发的定义，随后的上皮芽和肺管伸长。我们讨论了当前的模型和这些步骤中的实验证据。最后，我们讨论了间充质在确定器官特异性形状中的作用。
Branching morphogenesis generates epithelial trees which facilitate gas exchange, filtering, as well as secretion processes with their large surface to volume ratio. In this review, we focus on the developmental mechanisms that control the early stages of lung branching morphogenesis. Lung branching morphogenesis involves the stereotypic, recurrent definition of new branch points, subsequent epithelial budding, and lung tube elongation. We discuss current models and experimental evidence for each of these steps. Finally, we discuss the role of the mesenchyme in determining the organ-specific shape.
