论文标题
在生长的生物聚合物上分类交联的强大非平衡结合
A strong non-equilibrium bound for sorting of crosslinkers on growing biopolymers
论文作者
论文摘要
了解非平衡驱动在自组织中的作用对于开发生物系统的预测描述至关重要，但由于其复杂性而阻碍了它。肌动蛋白的细胞骨架是如何平衡和非平衡力结合起来产生自组织的范例。最近的实验激励表明，肌动蛋白细丝生长速率可以调节肌动蛋白束的增长的形态，并通过两种相互竞争的肌动蛋白结合蛋白交联，我们为这种系统构建了一个最小的模型，并表明该动力学受到一组热力学约束，与非平衡型驾驶，bunder bundle bundle bundle flux，bundle Morphology and Metercull flux和Morrecular Morphologulogy and Metercull flux和Marrecular flux相关联。热力学约束揭示了这些分子通量之间相关性的重要性，并为估算显微镜实验的显微镜驱动力提供了途径。
Understanding the role of non-equilibrium driving in self-organization is crucial for developing a predictive description of biological systems, yet it is impeded by their complexity. The actin cytoskeleton serves as a paradigm for how equilibrium and non-equilibrium forces combine to give rise to self-organization. Motivated by recent experiments that show that actin filament growth rates can tune the morphology of a growing actin bundle crosslinked by two competing types of actin binding proteins, we construct a minimal model for such a system and show that the dynamics are subject to a set of thermodynamic constraints that relate the non-equilibrium driving, bundle morphology, and molecular fluxes. The thermodynamic constraints reveal the importance of correlations between these molecular fluxes, and offer a route to estimating microscopic driving forces from microscopy experiments.
