论文标题
代谢网络的敏感性：扰动代谢物浓度
Sensitivity of metabolic networks: perturbing metabolite concentrations
论文作者
论文摘要
灵敏度研究网络对扰动的响应。我们考虑在平衡处的代谢产物浓度的局部扰动。我们研究网络中的反应，包括代谢产物浓度和反应通量。我们的方法纯粹是定性的，而不是定量的。实际上，我们的分析仅基于反应网络的化学计量法，我们不需要有关反应速率的任何定量信息。相反，描述仅以代数术语进行，而所需的唯一数据是网络结构。生物应用包括代谢控制和网络重建。
Sensitivity studies the network response to perturbations. We consider local perturbations of the concentrations of metabolites at an equilibrium. We investigate the responses in the network, both of the metabolite concentrations and of the reaction fluxes. Our approach is purely qualitative, rather than quantitative. In fact, our analysis is based, solely, on the stoichiometry of the reaction network and we do not require any quantitative information on the reaction rates. Instead, the description is done only in algebraic terms, and the only data required is the network structure. Biological applications include metabolic control and network reconstruction.
