论文标题
改进或失去它：表达竞争的可再发展成本
Improve it or lose it: evolvability costs of competition for expression
论文作者
论文摘要
已知表达水平是蛋白质进化速率的强大决定因素。但是相反的也可以是正确的：进化动力学会影响蛋白质的表达水平。在这两个方向上都有启示，这促进了反馈循环的可能性，在这种情况下，更高表达的系统更有可能改进并表达更高，而表达的系统最终却最终丢失了流漂移。使用最小模型在不断变化的环境的背景下研究这一点，我们证明了这种反馈循环的一个意外后果是，慢速切换到新环境可以使基因型比直接接触它更快地达到更高的适应性。
Expression level is known to be a strong determinant of a protein's rate of evolution. But the converse can also be true: evolutionary dynamics can affect expression levels of proteins. Having implications in both directions fosters the possibility of a feedback loop, where higher expressed systems are more likely to improve and be expressed even higher, while those that are expressed less are eventually lost to drift. Using a minimal model to study this in the context of a changing environment, we demonstrate that one unexpected consequence of such a feedback loop is that a slow switch to a new environment can allow genotypes to reach higher fitness sooner than a direct exposure to it.
