论文标题
患者特异性动脉瘘中的高富达血流
High fidelity blood flow in a patient-specific arteriovenous fistula
论文作者
论文摘要
通过人为地连接患者脉管系统的片段创建的动静脉瘘是获得肾脏透析血液的首选方法。超级计算基础设施的功率和可用性的增加意味着，使用模拟来帮助确定特定患者的瘘管的最佳类型和位置变得越来越现实。我们描述了一个3D瘘管模型，该模型使用晶格玻尔兹曼方法同时解决患者特异性动脉和静脉的血流。在此进行的模拟包括整个前臂的血管，显示出针对临床数据的合格验证。正在进行的研究以进一步涵盖现实时间尺度上的复杂生物物理学，将允许将人类规模的生理模型用于碱性和临床医学。
An arteriovenous fistula, created by artificially connecting segments of a patient's vasculature, is the preferred way to gain access to the bloodstream for kidney dialysis. The increasing power and availability of supercomputing infrastructure means that it is becoming more realistic to use simulations to help identify the best type and location of a fistula for a specific patient. We describe a 3D fistula model that uses the lattice Boltzmann method to simultaneously resolve blood flow in patient-specific arteries and veins. The simulations conducted here, comprising vasculatures of the whole forearm, demonstrate qualified validation against clinical data. Ongoing research to further encompass complex biophysics on realistic time scales will permit the use of human-scale physiological models for basic and clinical medicine.
