论文标题
人呼吸系统中SARS-COV2传播的分子通信理论建模和分析
Molecular Communication Theoretical Modeling and Analysis of SARS-CoV2 Transmission in Human Respiratory System
论文作者
论文摘要
严重的急性呼吸道综合征 - 甲状腺病毒2（SARS-COV2）引起了持续的大流行。截至2020年10月，这种大流行通过杀死了超过一百万的人来破坏世界。必须了解SARS-COV2的传播动态，以便可以开发出新颖和跨学科的预防，诊断和治疗技术。在这项工作中，我们从分子通信的角度对SARS-COV2的传播进行建模和分析。我们认为病毒扩散发生在粘液层中，因此该道的形状对透射没有显着影响。因此，该模型降低了人类呼吸系统的固有复杂性。我们进一步提供了SARS-COV2-ACE2受体结合事件的脉冲反应，以确定到达呼吸道不同区域的病毒群体的比例。我们的发现证实了有关较高的粘液流速的实验文献结果，导致病毒迁移到下呼吸道。这些结果对于了解SARS-COV2对不同年龄段的不同年龄段的不同年龄段的粘液流速和ACE2受体浓度在呼吸道不同区域的不同人群的影响尤为重要。
Severe Acute Respiratory Syndrome-CoronaVirus 2 (SARS-CoV2) caused the ongoing pandemic. This pandemic devastated the world by killing more than a million people, as of October 2020. It is imperative to understand the transmission dynamics of SARS-CoV2 so that novel and interdisciplinary prevention, diagnostic, and therapeutic techniques could be developed. In this work, we model and analyze the transmission of SARS-CoV2 through the human respiratory tract from a molecular communication perspective. We consider that virus diffusion occurs in the mucus layer so that the shape of the tract does not have a significant effect on the transmission. Hence, this model reduces the inherent complexity of the human respiratory system. We further provide the impulse response of SARS-CoV2-ACE2 receptor binding event to determine the proportion of the virus population reaching different regions of the respiratory tract. Our findings confirm the results in the experimental literature on higher mucus flow rate causing virus migration to the lower respiratory tract. These results are especially important to understand the effect of SARS-CoV2 on the different human populations at different ages who have different mucus flow rates and ACE2 receptor concentrations in the different regions of the respiratory tract.
