论文标题
考虑男性和女性的监管毒理学中体内生物测定的统计评估
Statistical evaluation of in-vivo bioassays in regulatory toxicology considering males and females
论文作者
论文摘要
对男性和女性的单独评估是使用Dunnett测试的剂量或治疗效果的最新体内毒理学标准。逐性互动的替代预测试是有问题的。在这里，考虑了两个性别特异性和合并的邓内特型比较，提出了联合测试。使用真实的数据示例，证明了同时置信区间或与R-Package MultComp的调整后的P值的计算。
The separate evaluation for males and females is the recent standard in in-vivo toxicology for dose or treatment effects using Dunnett tests. The alternative pre-test for sex-by-treatment interaction is problematic. Here a joint test is proposed considering the two sex-specific and the pooled Dunnett-type comparisons. The calculation of either simultaneous confidence intervals or adjusted p-values with the R-package multcomp is demonstrated using a real data example.
