论文标题
在渗透挑战下，海马电路中低频局部场振荡的分析和建模：精氨酸加压素回路对海马功能的可能作用
Analysis and modeling of low frequency local field oscillations in a hippocampus circuit under osmotic challenge: the possible role of arginine vasopressin circuit for hippocampal function
论文作者
论文摘要
电生理时间序列在大鼠大脑的海马中同时取走，先前被描述为从下丘脑的渗透敏感性加压素能神经元接收神经。在实验期间，对高渗性盐溶液注射进行了注射。我们使用不同的方法分析了记录的时间序列。在注射引起的扰动之后，我们检测到三角洲和theta振荡的修饰。我们比较了每种方法所表现出的每种方法的质量和信息，并基于假设分析了扰动的特征，即加压蛋白能力下丘脑巨细胞神经元之间功能连接的强度及其在神发瘤中的靶标在神发膜中的攻击性。我们建立了一个假设神经连接的模型，并在模拟盐水注入引起的扰动时计算系统产生的时间序列。理论结果类似于有关三角洲和theta频段的频率和振幅变化的实验发现。
Electrophysiological time series were taken simultaneously in two locations in the hippocampus of a rat brain previously described as receiving innervation from the osmosensitive vasopressinergic neurons of the hypothalamus. A hyperosmotic saline solution injection was administered during the time of the experiment. We analyze the recorded time series using different methods. We detect a modification of the delta and theta oscillations just after the perturbation caused by the injection. We compare the quality and information that each one of the methods exhibit and we analyze the characteristics of the perturbation based on a hypothesis that the strength of the functional connections between the vasopressinergic hypothalamic magnocellular neurons and their target in the hippocampus is modified by the perturbation. We built a model of the hypothetic neural connections and numerically calculate the time series produced by the system when simulating the perturbation caused by the saline injection. The theoretical results resemble the experimental findings concerning the frequency and amplitude alterations of the delta and theta bands.
