论文标题
细胞球体的液压和电控制
Hydraulic and electric control of cell spheroids
论文作者
论文摘要
我们使用一种理论方法来检查径向流体流或电流对细胞球体生长和稳态的影响。这种条件可以通过微米直径的排水产生。为了进行此分析，我们将组织描述为连续性。我们在组织材料特性中包括主动的机械，电和液压成分。我们考虑了球形几何形状，并研究了漏极对细胞骨料动力学的影响。我们表明，排水管施加的稳定流体流或电流可以显着改变球体的长时间状态。特别是，我们的工作表明，如果采用适当的外部场，则可以系统地将越来越多的球体驱动到缩小状态。魔术估计的顺序估计表明，此类田地是土著人的顺序。简要讨论了与肿瘤和胚胎发育的相似性和差异。
We use a theoretical approach to examine the effect of a radial fluid flow or electric current on the growth and homeostasis of a cell spheroid. Such conditions may be generated by a drain of micrometric diameter. To perform this analysis, we describe the tissue as a continuum. We include active mechanical, electric, and hydraulic components in the tissue material properties. We consider a spherical geometry and study the effect of the drain on the dynamics of the cell aggregate. We show that a steady fluid flow or electric current imposed by the drain could be able to significantly change the spheroid long-time state. In particular, our work suggests that a growing spheroid can systematically be driven to a shrinking state if an appropriate external field is applied. Order-of-magnitude estimates suggest that such fields are of the order of the indigenous ones. Similarities and differences with the case of tumors and embryo development are briefly discussed.
