论文标题
使用伪值分析限制的平均生存时间曲线之间的差异
Analyzing differences between restricted mean survival time curves using pseudo-values
论文作者
论文摘要
危险比在及时使用事件分析来量化治疗效果。尽管危害比对于假设检验是无价的，但其他相对和绝对措施的其他关联措施可用于充分阐明研究结果。群体之间的平均生存时间差异有限，已被提倡作为有用的关联度量。最近的工作集中在所有随访时间的限制平均存活率差异的无模型估计上，而不是专注于单个时间范围。在这项工作中，提出了基于模型的替代方案，并使用伪值进行估计。提出了一种简单的方法，可以通过可用的软件易于实现。也可以计算曲线的置信区域。作为副产品，还研究了参数“直到治疗平衡”（TUTE）。交叉存活曲线的示例将用于说明不同的方法以及一些模拟。
Hazard ratios are ubiquitously used in time to event analysis to quantify treatment effects. Although hazard ratios are invaluable for hypothesis testing, other measures of association, both relative and absolute, may be used to fully elucidate study results. Restricted mean survival time differences between groups have been advocated as useful measures of association. Recent work focused on model-free estimates of the difference in restricted mean survival for all follow-up times instead of focusing on a single time horizon. In this work a model-based alternative is proposed with estimation using pseudo-values. A simple approach is proposed easily implementable with available software. It is also possible to compute a confidence region for the curve. As a by-product, the parameter 'time until treatment equipoise' (TUTE) is also studied. Examples with crossing survival curves will be used to illustrate the different methods together with some simulations.
