论文标题
径向渗透表明癌症干细胞被困在肿瘤的核心中
Radial percolation reveals that Cancer Stem Cells are trapped in the core of tumorspheres
论文作者
论文摘要
使用几何论证，表明癌症干细胞（CSC）必须限制在自然情况下的实体瘤内。在基于代理的模型和渗透理论的帮助下，估计CSC处于菌落边界的概率。该概率估计是CSC自我更新概率$ p_s $的函数，即CSC在有丝分裂后变为非差异的机会。在最常见的情况下，$ P_S $很小，CSC大多注定要以非常低的速率生产差异化的单元。此处介绍的结果表明，CSC在癌细胞集落的中心形成了一个小核心，由于缺乏繁殖空间，稳定其人口大小，因此变得静止。该结果为CSC利基大小提供了一个简单的解释，该尺寸分配了需要进行群体感应或其他提出的信号传导机制。它还支持以下假设：转移可能在肿瘤发育的开始。
Using geometrical arguments it is shown that Cancer Stem Cells (CSC) must be confined inside solid tumors under natural situations. Aided by an agent-based model and percolation theory, the probability for a CSC to be at the border of a colony is estimated. This probability is estimated as a function of the CSCs self-renewal probability $p_s$, i.e. the chance that an CSC become non-differentiate after mitosis. In the most common situations, $p_s$ is small and CSCs are mostly destined to produce differentiated cells at a very low rate. The results presented here show that CSCs form a small core in the center of the cancer cell colony, becoming quiescent due to the lack of space to proliferate, which stabilizes their population size. This result provides a simple explanation for the CSC niche size that dispenses with the need of quorum sensing or other proposed signalling mechanisms. It is also supports the hypothesis that metastases are likely to start at the very beginning of the tumoral development.
