论文标题
淀粉样蛋白 - \ b {eta}的静电片和疏水片，寡聚物控制其分形自组装：对蛋白质的影响
Electrostatic and hydrophobic patches on Amyloid-\b{eta} oligomers govern their fractal self-assembly: Implication to proteins
论文作者
论文摘要
我们提出了一个通用模型，以描述蛋白质的分形自组装，以静电和疏水相互作用。该模型的预测与使用斑块扩散限制聚集获得的模拟分形相关，并使用共斑显微镜检查实验观察到的淀粉样蛋白\ b {eta}（a \ b {eta}）分形自我隔离。分子对接用于确定斑块在\ b {eta}低聚物上的特性。使用类似的斑块特性来设计颗粒进行模拟。与模型预测一致，模拟分形自组装的形成自由能与其分形维度成正比。此外，它们的形态类似于在不同pH下实验观察到的A \ b {eta}的分形形态。
We present a generic model to describe the fractal self-assembly of proteins in terms of electrostatic and hydrophobic interactions. The predictions of the model were correlated with the simulated fractals obtained using patchy diffusion-limited aggregation, and the experimentally observed Amyloid-\b{eta} (A\b{eta}) fractal self-assembly using confocal microscopy. The molecular docking was used to determine the properties of the patches on A\b{eta} oligomers. Similar patch properties were used to design the particles for simulation. In agreement with the model predictions, the free energy of formation for the simulated fractal self-assembly was proportional to its fractal dimension; moreover, their morphologies were similar to the fractal morphologies of A\b{eta} observed experimentally at different pH.
