论文标题
在协同抗菌肽的聚集状态下
On the Aggregation State of Synergistic Antimicrobial Peptides
论文作者
论文摘要
通过整合各种模拟和实验技术，我们发现抗菌肽（AMP）可以以最佳浓度和比率达到协同作用，这可能是由协同肽的聚集引起的。在多个时间和长度尺度上，我们的研究获得了溶液中肽共聚集的新证据，这可能会影响协同AMP对膜的破坏。我们的发现提供了有关AMP协同作用的复杂分子起源的关键细节，这将有助于指导协同AMP的未来发展以及抗感染肽鸡尾酒疗法的应用。
By integrating various simulation and experimental techniques, we discovered that antimicrobial peptides (AMPs) may achieve synergy at an optimal concentration and ratio, which can be caused by aggregation of the synergistic peptides. On multiple time and length scales, our studies obtain novel evidence of how peptide co-aggregation in solution can affect disruption of membranes by synergistic AMPs. Our findings provide crucial details about the complex molecular origins of AMP synergy, which will help guide the future development of synergistic AMPs as well as applications of anti-infective peptide cocktail therapies.
