论文标题
基于微管的肌动蛋白传输和球形细胞中的定位
Microtubule-based actin transport and localization in a spherical cell
论文作者
论文摘要
肌动蛋白丝与微管之间的相互作用对于许多真核细胞过程，例如细胞极化，细胞运动和细胞伤口愈合至关重要。长期以来，这种相互作用的重要性已被认识到，但几乎没有理解的基本机制以及对细胞细胞骨架的空间（RE）组织的后果。同时，了解不同生物分子成分之间相互作用的原因和后果是\ emph {Intter}研究的关键问题，涉及重组的生物分子系统，尤其是鉴于当前对创建最小合成细胞的兴趣的兴趣。从这个角度来看，最近的\ emph {Inter}实验表明，与肌动蛋白晶格和微管尖端结合的肌动蛋白 - 微管相互作用会导致肌动蛋白丝的有向转运。我们与肌动蛋白丝相互作用的动态不稳定微管的分析理论，该理论是从球形细胞中心核中的。我们表明，取决于未结合肌动蛋白丝的扩散与结合微管的倾向之间的平衡，肌动蛋白要么集中在细胞中心，在细胞的中心，微管的密度最高，要么变为细胞皮质。
The interaction between actin filaments and microtubules is crucial for many eukaryotic cellular processes, such as, among others, cell polarization, cell motility and cellular wound healing. The importance of this interaction has long been recognised, yet very little is understood about both the underlying mechanisms and the consequences for the spatial (re)organization of the cellular cytoskeleton. At the same time, understanding the causes and the consequences of the interaction between different biomolecular components are key questions for \emph{in vitro} research involving reconstituted biomolecular systems, especially in the light of current interest in creating minimal synthetic cells. In this light, recent \emph{in vitro} experiments have shown that the actin-microtubule interaction mediated by the cytolinker TipAct, which binds to actin lattice and microtubule tip, causes the directed transport of actin filaments. We develop an analytical theory of dynamically unstable microtubules, nucleated from the center of a spherical cell, in interaction with actin filaments. We show that, depending on the balance between the diffusion of unbound actin filaments and propensity to bind microtubules, actin is either concentrated in the center of the cell, where the density of microtubules is highest, or becomes localized to the cell cortex.
