论文标题
基于相似性的剩余网络选择,用于从单个观察结果预测大脑网络的演变轨迹
Residual Embedding Similarity-Based Network Selection for Predicting Brain Network Evolution Trajectory from a Single Observation
论文作者
论文摘要
尽管现有的预测框架能够处理欧几里得结构化数据(即大脑图像),但它们可能无法推广到几何非欧几里得数据,例如大脑网络。此外,它们是使用欧几里得人士或在矢量化训练和测试大脑网络之间学习的相似性度量的样本选择步骤的根源。这种样品连接组表示可能包括无关紧要的冗余特征,这些特征可能会误导训练样本选择步骤。毫无疑问,这无法利用并保留大脑连接的拓扑。为了克服这一主要缺点,我们提出了基于相似性网络选择(RESNET)的残留嵌入,以预测单个时间点的大脑网络演变轨迹。重置首先使用对抗性连接组嵌入网络对每个培训和测试样品进行紧凑的几何嵌入。这很好地降低了大脑网络的高维度,同时通过图形卷积网络保留其拓扑特性。接下来,为了计算受试者之间的相似性,我们介绍了连接脑模板(CBT)的概念,即固定的网络参考,我们进一步表示每个培训和测试网络作为偏离嵌入空间中参考CBT的偏差。因此,我们通过比较了预定义的CBT的剩余嵌入来选择基线时测试对象的最相似训练对象。一旦在基线中选择了最佳的训练样本,我们将在随访时间点上平均它们相应的大脑网络,以预测测试网络的演化轨迹。我们对健康和无序脑网络的实验证明了我们提出的方法的成功,与重新发放的灌输版本和传统方法相比。
While existing predictive frameworks are able to handle Euclidean structured data (i.e, brain images), they might fail to generalize to geometric non-Euclidean data such as brain networks. Besides, these are rooted the sample selection step in using Euclidean or learned similarity measure between vectorized training and testing brain networks. Such sample connectomic representation might include irrelevant and redundant features that could mislead the training sample selection step. Undoubtedly, this fails to exploit and preserve the topology of the brain connectome. To overcome this major drawback, we propose Residual Embedding Similarity-Based Network selection (RESNets) for predicting brain network evolution trajectory from a single timepoint. RESNets first learns a compact geometric embedding of each training and testing sample using adversarial connectome embedding network. This nicely reduces the high-dimensionality of brain networks while preserving their topological properties via graph convolutional networks. Next, to compute the similarity between subjects, we introduce the concept of a connectional brain template (CBT), a fixed network reference, where we further represent each training and testing network as a deviation from the reference CBT in the embedding space. As such, we select the most similar training subjects to the testing subject at baseline by comparing their learned residual embeddings with respect to the pre-defined CBT. Once the best training samples are selected at baseline, we simply average their corresponding brain networks at follow-up timepoints to predict the evolution trajectory of the testing network. Our experiments on both healthy and disordered brain networks demonstrate the success of our proposed method in comparison to RESNets ablated versions and traditional approaches.