论文标题
MOSGA：模块化开源基因组注释器
MOSGA: Modular Open-Source Genome Annotator
论文作者
论文摘要
由于测序技术的最新进展，即使对于大型真核基因组，高质量的组件的产生也已成为许多生物学家的日常任务。但是，这些组装的注释 - 释放感兴趣生物的生物学的关键步骤 - 仍然是一个复杂的挑战，通常需要先进的生物信息学专业知识。在这里，我们提出MOSGA，这是真核基因组的基因组注释框架，其用户友好的Web-Interface生成和集成了来自各种工具的注释。可以通过完全集成的基因组浏览器分析汇总结果，并以准备向NCBI提交的格式提供。 Mosga建立在便携式，可自定义且易于扩展的Snakemake后端，因此可以针对各种各样的用户和项目量身定制。我们在https://mosga.mathematik.uni-marburg.de上提供MOSGA作为公开免费的Web服务，并在Registry.gitlab.com/mosga/mosga/mosga:latest上提供Docker容器。可以在https://gitlab.com/mosga/mosga上找到源代码
The generation of high-quality assemblies, even for large eukaryotic genomes, has become a routine task for many biologists thanks to recent advances in sequencing technologies. However, the annotation of these assemblies - a crucial step towards unlocking the biology of the organism of interest - has remained a complex challenge that often requires advanced bioinformatics expertise. Here we present MOSGA, a genome annotation framework for eukaryotic genomes with a user-friendly web-interface that generates and integrates annotations from various tools. The aggregated results can be analyzed with a fully integrated genome browser and are provided in a format ready for submission to NCBI. MOSGA is built on a portable, customizable, and easily extendible Snakemake backend, and thus, can be tailored to a wide range of users and projects. We provide MOSGA as a publicly free available web service at https://mosga.mathematik.uni-marburg.de and as a docker container at registry.gitlab.com/mosga/mosga:latest. Source code can be found at https://gitlab.com/mosga/mosga
