论文标题
生物电系统的网络热力学建模：粘结图方法
Network Thermodynamical Modelling of Bioelectrical Systems: A Bond Graph Approach
论文作者
论文摘要
生物分子，电子和质子之间的相互作用对于维持生命的许多基本过程至关重要。因此，建立这些生物电过程的数学模型不仅是为了增强理解，还可以使计算机模型能够在体外和体内实验中进行补充。然而，重要的是，模型与物理原理兼容。用键图实现的网络热力学为创建物理兼容的生物电系统数学模型提供了一种方法。使用简单的离子通道，氧化还原反应，质子泵和电气膜转运蛋白的模型来说明这一点，从而证明该方法可用于构建各种生物电系统的数学和计算机模型。
Interactions between biomolecules, electrons and protons are essential to many fundamental processes sustaining life. It is therefore of interest to build mathematical models of these bioelectrical processes not only to enhance understanding but also to enable computer models to complement in vitro and in vivo experiments.Such models can never be entirely accurate; it is nevertheless important that the models are compatible with physical principles. Network Thermodynamics, as implemented with bond graphs, provide one approach to creating physically compatible mathematical models of bioelectrical systems. This is illustrated using simple models of ion channels, redox reactions, proton pumps and electrogenic membrane transporters thus demonstrating that the approach can be used to build mathematical and computer models of a wide range of bioelectrical systems.
