论文标题

修改的组织生长乘法分解模型:超出初始不应激状态

Modified multiplicative decomposition model for tissue growth: Beyond the initial stress-free state

论文作者

Du, Yangkun, Lü, Chaofeng, Chen, Weiqiu, Destrade, Michel

论文摘要

多种分解模型被广泛用于预测由于生长而引起的生物组织的残余应力和形态。但是,它依赖于组织最初处于无压力状态的假设,这与观察到任何生长状态的生长状态在显着的残余应力下有助于维持其理想的机械条件。在这里,我们提出了一个修改的乘法分解模型,其中生物组织的初始状态(或参考构型)赋予了残余应力,而不是不应激。从理论上释放最初的残留应力,最初的应力状态首先传播到虚拟应力状态,从而导致初始弹性变形。最初的虚拟无应力状态随后生长到另一个具有生长变形的对应物,后者进一步整合到其自然构型中,并具有过度的弹性变形,以确保组织兼容性。通过这种分解,总变形可以表示为弹性变形,生长变形和初始弹性变形的乘积,而相应的自由能密度取决于初始残留应力和总变形。我们解决了三个关键问题:自由能密度的明确表达,初始弹性变形的预先确定和初始残留应力。最后,我们考虑了一个管状器官,以通过增量稳定性分析来证明提出的初始残留应力对应力分布和形状形成的影响。我们的结果表明,初始残留应力对组织的生长应力和形态产生了重大影响。

The multiplicative decomposition model is widely employed for predicting residual stresses and morphologies of biological tissues due to growth. However, it relies on the assumption that the tissue is initially in a stress-free state, which conflicts with the observations that any growth state of tissue is under a significant level of residual stresses that helps to maintain its ideal mechanical conditions. Here, we propose a modified multiplicative decomposition model where the initial state (or reference configuration) of biological tissue is endowed with residual stress instead of being stress-free. Releasing theoretically the initial residual stress, the initially stressed state is first transmitted into a virtual stress-free state, resulting in an initial elastic deformation. The initial virtual stress-free state subsequently grows to another counterpart with a growth deformation and the latter is further integrated into its natural configuration with an excessive elastic deformation that ensures tissue compatibility. With this decomposition, the total deformation may be expressed as the product of elastic deformation, growth deformation and initial elastic deformation, while the corresponding free energy density depends on the initial residual stress and the total deformation. We address three key issues: explicit expression of the free energy density,predetermination of the initial elastic deformation, and initial residual stress. Finally, we consider a tubular organ to demonstrate the effects of the proposed initial residual stress on stress distribution and on shape formation through an incremental stability analysis. Our results suggest that the initial residual stress exerts a major influence on the growth stress and the morphology of tissues.

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