论文标题
激进对可能在XENON引起的全身麻醉中起作用
Radical pairs may play a role in xenon-induced general anesthesia
论文作者
论文摘要
了解全身麻醉的机制将是理解意识的关键步骤。 Xenon诱导的全身麻醉的过程已显示出涉及电子转移，并且XENON作为一般麻醉的效力表现出同位素依赖性。我们建议可以通过一种机制来解释这些观察结果，在这种机制中，氙核自旋影响天然发生的自由基电子对的重组动力学。我们开发了一个简单的模型，灵感来自于在鸟类磁受体的背景下对加密粉碎物中的激进对机理的工作，我们表明我们的模型可以重现小鼠Xenon普通麻醉效力的观察到的同位素依赖性。我们的结果与以下想法一致：与纠缠旋转的电子对对意识可能很重要。
Understanding the mechanisms underlying general anesthesia would be a key step towards understanding consciousness. The process of xenon-induced general anesthesia has been shown to involve electron transfer, and the potency of xenon as a general anesthetic exhibits isotopic dependence. We propose that these observations can be explained by a mechanism in which the xenon nuclear spin influences the recombination dynamics of a naturally occurring radical pair of electrons. We develop a simple model inspired by the body of work on the radical-pair mechanism in cryptochrome in the context of avian magnetoreception, and we show that our model can reproduce the observed isotopic dependence of the general anesthetic potency of xenon in mice. Our results are consistent with the idea that radical pairs of electrons with entangled spins could be important for consciousness.
