论文标题
帕金森氏病骨化性变性的多模式评估
Multimodal assessment of nigrosomal degeneration in Parkinson's disease
论文作者
论文摘要
背景:SNPC中所有多巴胺能神经元中约有40%位于五个致密的神经元簇中,称为Nigrosomes。 T2-或T2*加权图像用于描述最大的nigrosome,称为Nigrosome-1。在这些图像中,Nigrosome-1是T2-或T2*加权的黑质的尾骨和背侧部分的高强度区域。在PD中,Nigrosome-1经历铁的积累,从而导致T2加权高强度的降低。在这里,我们检查了源自基于定量 - 素的形态计量学(QVBM)在神经素敏感图像上的基于定量 - 素的形态计量学(QVBM)中的神经素蛋白 - 缺乏和铁沉积,并将ROI与T2越来越多的nigrosome-1进行比较。 方法:获得神经素素敏感和多回波梯度回声成像数据。 R2*是根据多回波梯度回声成像数据计算得出的。 QVBM分析对神经素敏感的图像进行,并限于SNPC。从产生的QVBM簇测量平均神经素敏感的对比度和R2*。 Nigrosome-1在T2*加权受试者的图像中进行了分割,并将其位置与QVBM簇的空间位置进行了比较。 结果:QVBM分析中出现了两个双侧簇。与对照组相比,这些簇显示出降低的神经苯胺敏感对比度和PD的平均R2*。 QVBM分析中的群集1与Nigrosome-1相似的空间位置,如T2*加权图像所示。 结论:QVBM群集1显示神经素敏感的对比度降低,并且与Nigrosome-1相似的空间位置。该区域可能对应于Nigrosome-1,而第二个簇可能对应于Nigrosome-2。
Background: Approximately forty percent of all dopaminergic neurons in SNpc are located in five dense neuronal clusters, named nigrosomes. T2- or T2*-weighted images are used to delineate the largest nigrosome, named nigrosome-1. In these images, nigrosome-1 is a hyperintense region in the caudal and dorsal portion of the T2- or T2*-weighted substantia nigra. In PD, nigrosome-1 experiences iron accumulation, which leads to a reduction in T2-weighted hyperintensity. Here, we examine neuromelanin-depletion and iron deposition in regions of interest (ROIs) derived from quantitative-voxel based morphometry (qVBM) on neuromelanin-sensitive images and compare the ROIs with nigrosome-1 identified in T2*-weighted images. Methods: Neuromelanin-sensitive and multi-echo gradient echo imaging data were obtained. R2* was calculated from multi-echo gradient echo imaging data. qVBM analysis was performed on neuromelanin-sensitive images and restricted to SNpc. Mean neuromelanin-sensitive contrast and R2* was measured from the resulting qVBM clusters. Nigrosome-1 was segmented in T2*-weighted images of control subjects and its location was compared to the spatial location of the qVBM clusters. Results: Two bilateral clusters emerged from the qVBM analysis. These clusters showed reduced neuromelanin-sensitive contrast and increased mean R2* in PD as compared to controls. Cluster-1 from the qVBM analysis was in a similar spatial location as nigrosome-1, as seen in T2*-weighted images. Conclusion: qVBM cluster-1 shows reduced neuromelanin-sensitive contrast and is in a similar spatial position as nigrosome-1. This region likely corresponds to nigrosome-1 while the second cluster may correspond to nigrosome-2.